Publications

ORCID IDhttps://orcid.org/0000-0001-9067-8664

Web of Science ResearcherIDA-7878-2010

63. “Direct C-H Functionalization of Phenanthrolines: Metal- and Light-Free Dicarbamoylations” D. T. Mooney, B. D. T. Donkin, N. Demirel, P. R. Moore and A.‑L. Lee* J. Org. Chem. 2021, accepted. https://doi.org/10.1021/acs.joc.1c02425

62. “Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification” C. G. Thomson, C. Banks, M. Allen, G. Barker, C. R. Coxon, A.-L. Lee* and F. Vilela* J. Org. Chem. 2021, 86, 14079. https://doi.org/10.1021/acs.joc.1c01151.

Part of the Enabling Techniques for Organic Synthesis special issue.

61. “Selectivity Control in Gold-Catalyzed Hydroarylation of Alkynes with Indoles: Application to Unsymmetrical Bid(indolyl)methanes” E. B. McLean, F. M. Cutolo, O. J. Cassidy, D. J. Burns and A.-L. Lee,* Org. Lett., 2020, 22, 6977. Abstract

60. “Heterogeneous Photocatalysis in Flow Chemical Reactors” C. G. Thomson, A.-L. Lee* and F. Vilela,* Beilstein J. Org. Chem., 2020, 16, 1495. Open Access

59. “Continuous-Flow Synthesis and Application of Polymer-Supported BODIPY Photosensitisers for the Generation of Singlet Oxygen; Process Optimised by In-Line NMR Spectroscopy” C. G. Thomson, C. M. S. Jones, G. M. Rosair, D. Ellis, J. Marques-Hueso, A.-L. Lee and F. Vilela,* J. Flow. Chem., 2020, 10, 327. Open Access

58. “Synthesis and Optoelectronic Properties of Benzoquinone-Related Donor-Acceptor Compounds” D. R. Sutherland, N. Sharma, G. M. Rosair, I. D. W. Samuel,* A.-L. Lee* and E. Zysman-Colman,* Beilstein J. Org. Chem., 2019, 15, 2914. Open Access

57. “Pd(II)-Catalyzed Enantioselective Desymmetrization of Polycyclic Cyclohexenediones: Conjugate Addition versus Oxidative Heck” C. J. C. Lamb, F. Vilela and A.-L. Lee,* Org. Lett., 2019, 21, 8689.  Abstract

56. “Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles” M. T. Westwood, C. J. C Lamb, D. R. Sutherland and A.-L. Lee,* Org. Lett., 2019, 21, 7199. Abstract.

55. “Golden Potential” E. B. McLean and A.-L. Lee,* Nat. Chem., 2019, 11, 760. -Invited “News and Views” article discussing Mouriès-Mansuy, Ollivier and Fensterbank’s elegant energy transfer photoexcitation process in dual gold and photoredox catalysis.  Article

54. “Dual Copper- and Photoredox-Catalysed C(sp2)–C(sp3) Coupling” E. B. McLean, V. Gauchot, S. Brunen, D. J. Burns and A.-L. Lee,* Chem. Commun., 2019, 55, 4238. Abstract

53. “Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations” M. Veguillas, G. M. Rosair, M. W. P. B. Bebbington,* A.-L. Lee,* ACS Catal., 20199, 2552. Open Access

52. “Metal-, Photocatalyst-, and Light-Free, Late-Stage CH Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids” D. R. Sutherland, M. Veguillas, C. L. Oates, A.-L. Lee,* Org. Lett., 2018, 20, 6863. Abstract.

51. “Dual Copper- and Photoredox-Catalysed Reactions” E. B. McLean, A.-L. Lee,* Tetrahedron, 2018, 74, 4881.  Abstract. -Invited Review for “Barton Centennial Symposium In Print” Special Issue

50. “Gold(I)-Catalysed Hydroarylation of 1,3‑Disubstituted Allenes with Efficient Axial-to-Point Chirality Transfer“ D. R. Sutherland, L. Kinsman, S. M. Angiolini, G. M. Rosair, A.-L. Lee,* Chem. Eur. J., 2018, 24, 7002. Abstract. -“Very Important Paper” See tweet.

49. “Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes” S. Webster, K. M. O’Rourke, C. Fletcher, S. L. Pimlott, A. Sutherland, A.-L. Lee, Chem. Eur. J., 201824, 937-943. Open Access -Highlighted in Synfacts (contributors: Timothy M. Swager and Martin D. Peeks) Synfacts201814 (04), 365. Link

48. “Auto-Tandem Catalysis: Pd(II)-Catalysed Dehydrogenation/Oxidative Heck of Cyclopentane-1,3-diones” C. J. C. Lamb, B. G. Nderitu, G. McMurdo, J. M. Tobin, F. Vilela, A.-L. Lee, Chem. Eur. J., 201723, 18282-18288. Open Access

47. “Dual Gold and Photoredox Catalysed C-H Activation of Arenes for Aryl-Aryl Cross Couplings ” V. Gauchot, D. R. Sutherland, A.-L. Lee, Chem. Sci20178, 2885-2889 Open Access.

46. “Chirality Transfer in Gold(I)-Catalysed Hydroalkoxylation of 1,3-Disubstituted Allenes” S. Webster, D. R. Sutherland, A.-L. Lee, Chem. Eur. J2016, 22,  18593–18600. Open Access. -“Hot Paper”and Highlighted on ChemistryViews website

45. “Dual Gold Photoredox C(sp2)-C(sp2) Cross Couplings – Development and Mechanistic Studies” V. Gauchot, A.-L. Lee, Chem. Commun201652, 10163. Open Access.

44. “Enantioselective Oxidative Boron Heck Reactions” A.-L. Lee, Org. Biomol. Chem.201614, 5357.Abstract -Invited Review Article: New Talent Special Issue

43. “A Rotaxane with a Golden Touch” A.-L. Lee, Nat. Chem.20168, 8.Article -Invited “News and Views” article discussing a new gold-rotaxane catalyst by the Goldup Group.

42. “Indium vs. Gold Catalysis in Dehydrative Reactions with Allylic Alcohols” S. Webster, L. Schaefer, G. Barker, A.-L. Lee, Synlett201526, 2673. Abstract -Invited Article: Young Investigators Workshop – SYNLETT Special Issue

41. “Chirality Transfer in Gold(I)-Catalysed Direct Allylic Etherification of Unactivated Alcohols – Experimental and Computational Study” G. Barker, D. G. Johnson, P. C. Young, S. A. Macgregor, A.-L. Lee, Chem. Eur. J.201521, 13748Open Access

40. “Gold-Catalyzed Proto- and Deutero-deboronation” G. Barker, S. Webster, D. G. Johnson, R. Curley, M. Andrews, P. C. Young, S. A. Macgregor, A.-L. Lee, J. Org. Chem201580, 9807. Open Access

  • Cover and Featured Article, Issue 20
  • Highlighted in Synfacts 2015, 11, 1093, Contributors: P. Knochel and D. Haas. Abstract
  • Highlighted in Organic Chemistry Portal abstracts.

39. “Oxidative Heck Desymmetrisation of 2,2-Disubstituted Cyclopentene-1,3-diones” S. E. Walker, C. J. C. Lamb, N. A. Beattie, P. Nikodemiak, A.-L. Lee, Chem. Commun.2015,51, 4089-4092. Open Access Article

38. “Dehydrative Thiolation of Allenols – Indium vs. Gold Catalysis” S. Webster, P. C. Young, G. Barker, G. M. Rosair, A.-L. Lee, J. Org. Chem.201580, 1703-1708. Abstract.

37. “Pd-Catalyzed Direct C-H Functionalization of Benzoquinone” S. E. Walker, J. A. Jordan-Hore, D. G. Johnson, S. A. Macgregor, A.-L. Lee, Angew. Chem. Int. Ed.201453, 13876-13879. Open Access Article.

36. “Gold(I)-Catalysed Direct Thioetherifications using Allylic Alcohols – an Experimental and Computational Study” L. Herkert, S. L. J. Green, G. Barker, D. G. Johnson, P. C. Young, S. A. Macgregor, A.-L. Lee, Chem. Eur. J.201420, 11540-11548. Open Access Article.

35. “Gold(I) and Palladium(II) Complexes of 1,3,4-Trisubstituted 1,2,3-Triazol-5-ylidene Click Carbenes: Systematic Study of the Electronic and Steric Influence on Catalytic Activity”, J. R. Wright, P. C. Young, N. T. Lucas, A.-L. Lee, J. D. Crowley, Organometallics., 201332, 7065-7076. Open Access Article

34. “Gold(I)-Catalysed One-Pot Synthesis of Chromans using Allylic Alcohols and Phenols”, E. Coutant, P. C. Young, G. Barker, A.-L. Lee, Beilstein J. Org. Chem., 20139, 1797-1806. Open Access Article. -Invited Article: “Gold Catalysis for Organic Synthesis II” Thematic Series.

33. “Deactivation of Gold(I) Catalysts in the Presence of Thiols and Amines – Characterisation and Catalysis”, P. C. Young, S. L. J. Green, G. M. Rosair, A.-L. Lee, Dalton Trans., 201342, 9645-9653. Open Access Article

32. “Ligand and Base-free Pd(II)-Catalyzed Controlled Switching between Oxidative Heck and Conjugate Addition Reactions”, S. E. Walker, J. Boehnke, P. E. Glen, S. Levey, L. Patrick, J. A. Jordan-Hore, A.-L. Lee, Org. Lett.201315, 1886-1889. Abstract.

31. “Organocatalyzed Carbonyl–Olefin Metathesis”, A.-L. Lee, Angew. Chem. Int. Ed.2013, 52, 4524. Abstract. -Invited Highlight on Lambert’s carbonyl-olefin metathesis work

30. “Gold(I)-Catalysed Direct Allylic Etherification of Unactivated Alcohols”, P. C. Young, N. A. Schopf, A.-L. Lee, Chem. Commun.201349, 4262-4264. Abstract.

  • Invited article: Emerging Investigators Special Issue, 2013.
  • “HOT” Article – available free of charge from Chem. Commun. website until 14th December 2012.
  • Read the Chem. Commun. blog about this work here.
  • Highlighted in Organic Chemistry Highlights, October 2013 on the Organic Chemistry Portal.

29. “Synthesis of a C1-Symmetric Box Macrocycle and Studies toward Active Template Synthesis of Mechanically Planar Chiral Rotaxanes”, P. E. Glen, J. A. T. O’Neill, A.-L. Lee, Tetrahedron, 2013, 67, 57-68. Abstract.

28. “Gold(I)-Catalyzed Addition of Thiols and Thioacids to 3,3-Disubstituted Cyclopropenes”, R. J. Mudd, P. C. Young, J. A. Jordan-Hore, G. Rosair, A.-L. Lee, J. Org. Chem., 201277, 7633–7639 Abstract

27. “Gold(III)-oxo complexes as catalysts in intramolecular hydroamination”, J. A. T. O’Neill, G. M. Rosair, A.-L. Lee, Catal. Sci. Technol., 20122, 1818-1821. Abstract

26. “Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones”, J. A. Jordan-Hore, J. N. Sanderson, A.-L. Lee, Org. Lett.201214, 2508-2511. Abstract -Highlighted on the Organic Chemistry Portal website.

25. “Computational Studies on the Mechanism of the Gold(I)-Catalysed Rearrangement of Cyclopropenes”, M. S. Hadfield, L. J. Häller, A.-L. Lee, S. A. Macgregor, J. A. T. O’Neill, A. M. Watson, Org. Biomol. Chem., 201210, 4433-4440. Abstract

24. “Divergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes”, P. C. Young, M. S. Hadfield, L. Arrowsmith, K. M. Macleod, R. J. Mudd, J. A. Jordan-Hore, A.-L. Lee, Org. Lett., 2012, 14, 898-901. Abstract

23. “1,3,4-Trisubstituted-1,2,3-Triazol-5-ylidene ‘Click’ Carbene Ligands: Synthesis, Catalysis and Self-Assembly”, J. D. Crowley, A.-L. Lee, K. J. Kilpin, Aust. J. Chem.201164, 1118–1132. Review in the ‘Research Front’ issue on N-heterocyclic carbenes. Abstract -Ranked top 5 “Most Read” based on number of downloads (July 2012)

22. “Enantioselective Catalysis”, A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem.2011, 107, 369–389. Abstract

– This review highlights significant advances in the field of enantioselective catalysis in 2010. Key advances in enantioselective gold-catalysed reactions, palladium-catalysed Heck reactions and alkene metathesis will be emphasised.

21. “Gold(I)-Catalysed Iodoalkoxylation of Allenes”, A. Heuer-Jungemann, R. G. McLaren, M. S. Hadfield, A.-L. Lee, Tetrahedron201167, 1609 – 1616. Abstract

20. “Gold(I)-catalysed Synthesis of Conjugated Trienes”, M. S. Hadfield, A.-L. Lee, Chem. Commun., 2011, 47, 1333 – 1335. Abstract

19. “Gold(I) “Click” 1,2,3-Triazolylidenes: Synthesis, Self-assembly and Catalysis”, K. J. Kilpin, U. S. D. Paul, A.-L. Lee, J. D. Crowley, Chem. Commun., 201147, 328 – 330 (Emerging Investigators Theme Issue). Abstract

18. “Gold(I)-Catalysed Alcohol Additions to Cyclopropenes”, M. S. Hadfield, J. T. Bauer, P. E. Glen, A.-L. Lee, Org. Biomol. Chem.20108, 4090 – 4095. Abstract

17. “Enantioselective Catalysis”, A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem.2010106, 428-446. Abstract – This review highlights significant advances in the field of enantioselective catalysis in 2009. Key advances in enantioselective gold-catalysed reactions and alkene metathesis are emphasised.

16. “Regioselective Synthesis of tert-Allylic Ethers via Gold(I)-Catalyzed Intermolecular Hydroalkoxylation of Allenes”, M. S. Hadfield, A.-L. Lee, Org. Lett., 201012, 484-487. Abstract

  • Highlighted in Synfacts 2010,0573, Contributors: H. Yamamoto and K. Griffin. Abstract

15. “Enantioselective Catalysis”, A.-L. Lee, Annu. Rep. Prog. Chem., Sect. B: Org. Chem.2009105, 421-439. Abstract -This review highlights significant advances in the field of asymmetric synthesis, with a mechanistic and catalysis flavour. Since this is the first review in Annual Reports B on this series, major advances from 2008 as well as a few older papers are covered. Key advances in enantioselective Heck couplings, alkene metathesis and catalysis by interlocked architectures are emphasised.

14. “Gold Catalysed Reactions with Cyclopropenes”, J. T. Bauer, M. S. Hadfield, A.-L. Lee, Chem. Commun.2008, 6405-6407. Abstract

Publications from Ai-Lan’s postdoctoral and PhD studies:

13. “Active metal template synthesis of rotaxanes, catenanes and molecular shuttles”, J. D. Crowley, S. M. Goldup, A.-L. Lee, D. A. Leigh and R. T. McBurney, Chem. Soc. Rev.200938, 1530-1541. Abstract

12. “Cadiot-Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions”, J. Berna, S.M. Goldup, A.-L. Lee, D. A. Leigh, M. D. Symes, G. Teobaldi and F. Zerbetto, Angew. Chem. Int. Ed., 200847, 4392-4396. Abstract

11. “[2]Rotaxanes through Palladium Active-Template Oxidative Heck Cross-Couplings”, J. D. Crowley, K. Haenni, A.-L. Lee, D. A. Leigh, J. Am. Chem. Soc., 2007, 129, 12092-12093. Abstract -Highlighted in Synfacts 2007, 1257, Contributors: T. M. Swager, B. VanVeller. Abstract

10. “A Catalytic Palladium Based Active-Metal Template Pathway to [2]Rotaxanes”, J. Berna, J. D. Crowley, S. M. Goldup, K. Haenni, A.-L. Lee, D. A. Leigh, Angew. Chem. Int. Ed., 2007, 46, 5709-5713. Abstract

9.“Operationally Simple, Efficient and Diastereoselectvie Synthesis of Cis-2,6-Disubstituted-4-methylene Tetrahydropyrans Catalyzed by Triflic Acid”, A. Puglisi A.-L. Lee, R. R. Schrock, A. H. Hoveyda, Org. Lett., 20068, 1871-1874. Abstract

8. “Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centres through Catalytic Asymmetric Ring-Closing Metathesis”, A.-L. Lee, S. Malcolmson, A. Puglisi, R. R. Schrock, A. H. Hoveyda, J. Am. Chem. Soc., 2006128, 5153-5157. Abstract

7. “Integrated Microwave Assisted Synthesis and Solid-Supported Reagents”, I.R. Baxendale, A.-L. Lee and S.V. Ley. In Microwave Assisted Organic Chemistry. Ed. J. P. Tierney and P. Lidstrom, Blackwells, 2005, ISBN 1405115602. Link

6. “The Synthesis of the Anti-malarial Natural Product Polysphorin and Analogues Using Polymer-supported Reagents and Scavengers”, A-L. Lee, S.V. Ley, Org. Biomol. Chem., 20031, 3957-3966. Abstract

5. “Microencapsulation of Osmium Tetroxide in Polyurea”, S.V. Ley, C. Ramarao, A.-L. Lee, N. Östergaard, S.C. Smith, I.M. Shirley, Org. Lett.20035, 185-187. Abstract

4. “A Concise Synthesis of Carpanone Using Solid-Supported Reagents and Scavengers”, I.R. Baxendale, A.-L. Lee, S.V. Ley, J. Chem. Soc., Perkin Trans. 12002, 1850-1857. Abstract

3. “A Polymer-supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds”, I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett2002, 516-518. Abstract

2. “A Concise Synthesis of the Natural Product Carpanone Using Solid-Supported Reagents and Scavengers”, I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett2001, 1482-1484; Errata, I.R. Baxendale, A.-L. Lee, S.V. Ley, Synlett2001, 2004. Abstract

1. “Polymer Supported Hydroxide”, S.V. Ley, I.R. Baxendale and A.-L. Lee. In Electronic Encyclopedia of Reagents for Organic Synthesis Ed. L.A. Paquette, J. Wiley, 2001Abstract